Drug Information

Drug General Information
Drug ID
D0F4HJ
Former ID
DIB016874
Drug Name
5-HT 6 antagonists
Synonyms
IDDBCP245491
Indication Obesity [ICD9: 278; ICD10:E66] Investigative [552018]
Company
Bristol-Myers Squibb Co
Canonical SMILES
c1cccc(c1)S(=O)(=O)c1c(nc2n(c1=N)cccc2)SC
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [543365]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 552018Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile. J Med Chem. 2003 Nov 6;46(23):4834-7.
Ref 543365(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11).

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