Drug Information

Drug General Information
Drug ID
D0F2XI
Former ID
DIB018619
Drug Name
4BP-TQS
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540583]
Formula
C18H17BrN2O2S
InChI
InChI=1S/C18H17BrN2O2S/c19-12-6-4-11(5-7-12)18-15-3-1-2-14(15)16-10-13(24(20,22)23)8-9-17(16)21-18/h1-2,4-10,14-15,18,21H,3H2,(H2,20,22,23)
InChIKey
YNCXHXYZTLIZTO-UHFFFAOYSA-N
PubChem Compound ID
2857838
PubChem Substance ID
3367598, 5612708, 8079882, 10084873, 11521941, 40824790, 48365961, 48476475, 74428029, 89203403, 92192754, 108067874, 111482730, 124543745, 160872272, 162017496, 169038561, 178100788, 181747639, 196370508, 215732891, 252157895, 252543545
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Agonist [531407]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 540583(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3962).
Ref 531407Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5867-72.

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