Drug Information

Drug General Information
Drug ID
D0EN4G
Former ID
DIB002680
Drug Name
R-102444
Synonyms
Dopamine D2 antagonists, Sankyo; 5-HT2 antagonists, Sankyo
Indication Pancreatitis [ICD9: 577.0-577.1; ICD10:K85, K86.0K86.1] Terminated [547365]
Company
Sankyo Co Ltd
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Modulator [535964]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547365Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015510)
Ref 535964Effects of R-102444, an orally active 5-HT2A receptor antagonist, in rat models of peripheral vascular disease. Vascul Pharmacol. 2004 Feb;41(1):7-13.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.