Drug Information

Drug General Information
Drug ID
D0EI1U
Former ID
DNCL002119
Drug Name
DCDT-2980S
Drug Type
Antibody
Indication Non-hodgkin's lymphoma; Diffuse large B-cell lymphoma [ICD9: 200, 200.0, 202; ICD10:C82-C85, C83.3] Discontinued in Phase 2 [548683]
Company
Genentech
Target and Pathway
Target(s) B-cell receptor CD22 Target Info [544284]
KEGG Pathway Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
B cell receptor signaling pathway
PANTHER Pathway B cell activation
Pathway Interaction Database BCR signaling pathway
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways B Cell Receptor Signaling Pathway
References
Ref 548683Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027651)
Ref 544284Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin's lymphoma. Oncoimmunology. 2012 December 1; 1(9): 1469-1475.

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