Drug Information

Drug General Information
Drug ID
D0E5YG
Former ID
DCL000454
Drug Name
AZD1236
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 2 [542784], [548572]
Company
AstraZeneca
Formula
C15H19ClN4O5S
InChI
InChI=1S/C15H19ClN4O5S/c1-15(13(21)18-14(22)19-15)9-26(23,24)20-6-4-11(5-7-20)25-12-3-2-10(16)8-17-12/h2-3,8,11H,4-7,9H2,1H3,(H2,18,19,21,22)/t15-/m1/s1
InChIKey
SFJFBTPHDHUUPU-OAHLLOKOSA-N
PubChem Compound ID
24751752
PubChem Substance ID
49654074, 56166888, 137835663, 163417484, 163850437, 172860917, 189053695, 223366174, 223622763, 227203611, 247855836, 252495249
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [550288]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 542784(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7844).
Ref 548572Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026714)
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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