Drug Information

Drug General Information
Drug ID
D0E5DB
Former ID
DIB014056
Drug Name
Laromustine
Synonyms
Cloretazine; Onrigin; Alkylating agents, Vion; SHP, Vion; Sulfonyl hydrazine prodrugs, Vion; VN-40101M; VNP-40101M; VNP-4090-CE; 90CE
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 3 [521645]
Company
Vion Pharmaceuticals Inc
Formula
C6H14ClN3O5S2
Canonical SMILES
N(N(S(=O)(=O)C)CCCl)(S(=O)(=O)C)C(=O)NC
CAS Number
CAS 173424-77-6
PubChem Compound ID
3081349
Target and Pathway
Target(s) Human DNA Target Info Binder [530948]
References
Ref 521645ClinicalTrials.gov (NCT00112554) Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 530948Phase I study of temozolomide and laromustine (VNP40101M) in patients with relapsed or refractory leukemia. Clin Lymphoma Myeloma Leuk. 2010 Jun;10(3):211-6.

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