Drug Information

Drug General Information
Drug ID
D0DY4E
Former ID
DNC008107
Drug Name
JNJ-17203212
Drug Type
Small molecular drug
Indication Cough [ICD9: 786.2; ICD10:R05] Investigative [467563]
Formula
C17H15F6N5O
InChI
InChI=1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
InChIKey
JFRYYGVYCWYIDQ-UHFFFAOYSA-N
PubChem Compound ID
11339118
PubChem Substance ID
16429931, 23500178, 44380395, 74718842, 99030150, 103562073, 104088245, 125697845, 134345312, 135698880, 141108902, 142634962, 162917785, 172113650, 174811353, 178101045, 196375755, 198947543, 204370506, 223928944, 226505698, 241376415, 246513241, 252157228, 252450348, 252543498
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Inhibitor [528825]
Vanilloid receptor Target Info Inhibitor [528825]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 467563(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4228).
Ref 528825J Med Chem. 2007 May 31;50(11):2589-96. Epub 2007 May 10.The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.

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