Drug Information

Drug General Information
Drug ID
D0D8FZ
Former ID
DNC013207
Drug Name
2-benzyl-N1-hydroxy-N3-phenethylmalonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528703]
Formula
C18H20N2O3
Canonical SMILES
C1=CC=C(C=C1)CCNC(=O)C(CC2=CC=CC=C2)C(=O)NO
InChI
1S/C18H20N2O3/c21-17(19-12-11-14-7-3-1-4-8-14)16(18(22)20-23)13-15-9-5-2-6-10-15/h1-10,16,23H,11-13H2,(H,19,21)(H,20,22)
InChIKey
GJBWQDWUWPUOOP-UHFFFAOYSA-N
PubChem Compound ID
16114889
Target and Pathway
Target(s) Aminopeptidase N Target Info Inhibitor [528703]
BioCyc Pathway Glutathione-mediated detoxification
KEGG Pathway Glutathione metabolism
Metabolic pathways
Renin-angiotensin system
Hematopoietic cell lineage
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Glutathione Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Cardiac Progenitor Differentiation
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
Glutathione metabolism
References
Ref 528703J Med Chem. 2007 Mar 22;50(6):1322-34. Epub 2007 Feb 28.Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.
Ref 528703J Med Chem. 2007 Mar 22;50(6):1322-34. Epub 2007 Feb 28.Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.

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