Drug Information

Drug General Information
Drug ID
D0C3UC
Former ID
DIB007180
Drug Name
Ladostigil
Synonyms
Ladostigil tartrate; Alzheimer disease therapeutics, Teva; TV-3219; TV-3279; TV-3326
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 2 [531772]
Company
Hebrew University of Jerusalem
Formula
C16H20N2O2
Canonical SMILES
C(=O)(Oc1cc2c(CC[C@H]2NCC#C)cc1)N(CC)C
PubChem Compound ID
208907
Target and Pathway
Target(s) Amine oxidase [flavin-containing] B Target Info Inhibitor [531772]
Amine oxidase [flavin-containing] A Target Info Inhibitor [531772]
Acetylcholinesterase Target Info Inhibitor [531772]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation II
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholismhsa00260:Glycine, serine and threonine metabolism
Alcoholismhsa00564:Glycerophospholipid metabolism
Cholinergic synapse
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Dopamine receptor mediated signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database Alpha-synuclein signalingatf2_pathway:ATF-2 transcription factor network
PathWhiz Pathway Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine MetabolismPW000048:Phospholipid Biosynthesis
Reactome Norepinephrine Neurotransmitter Release Cycle
WikiPathways Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compoundsWP706:SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Oxidative Stress
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter ActivityWP727:Monoamine Transport
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 531772Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
Ref 531772Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.

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