Drug Information

Drug General Information
Drug ID
D0B0GC
Former ID
DIB000477
Drug Name
E-0722
Synonyms
Methosorbinil; E-79175; M-79175
Drug Type
Small molecular drug
Indication Diabetic cataract [ICD10:E10.36, E11.36] Terminated [545784]
Company
Eisai Co Ltd
Formula
C12H11FN2O3
Canonical SMILES
[C@]12(C(=O)NC(=O)N1)c1c(O[C@@H](C2)C)ccc(c1)F
CAS Number
CAS 102916-95-0
PubChem Compound ID
175915
Target and Pathway
Target(s) Aldose reductase Target Info Modulator [533052]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 545784Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004685)
Ref 533052Aldose reductase inhibitors and prevention of galactose cataracts in rats. Invest Ophthalmol Vis Sci. 1989 Jul;30(7):1623-32.

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