Drug Information

Drug General Information
Drug ID
D0AT8C
Former ID
DAP000395
Drug Name
Pegfilgrastim
Synonyms
Neulasta; Neulasta (TN); Pegfilgrastim (INN)
Drug Type
Small molecular drug
Indication Non-myeloid cancer [ICD9: 140-199; ICD10:C00-C75, C7A, C7B] Approved [536361], [542001]
Therapeutic Class
Immunomodulatory Agents
Company
Amgen Inc
Formula
C27H46N4O19
CAS Number
CAS 208265-92-3
PubChem Compound ID
70683024
PubChem Substance ID
49661789
SuperDrug ATC ID
L03AA13
Target and Pathway
Target(s) Macrophage colony-stimulating factor receptor Target Info Binder [535943]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling Pathway
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542001(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6969).
Ref 535943Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. Pharmacol Res. 2004 Jul;50(1):55-8.

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