Drug Information

Drug General Information
Drug ID
D0AM8W
Former ID
DIB010275
Drug Name
Zanapezil
Synonyms
TAK-147
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Discontinued in Phase 3 [545741]
Company
Takeda Pharmaceutical Co Ltd
Formula
C25H32N2O
Canonical SMILES
c12cc(C(=O)CCC3CCN(Cc4ccccc4)CC3)ccc2CCCCN1.C(=O)(/C=C/<br />C(=O)O)O
PubChem Compound ID
198752
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [527590]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 545741Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004496)
Ref 527590Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats. Br J Pharmacol. 2005 Aug;145(8):1035-44.

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