Drug Information

Drug General Information
Drug ID
D0A9PW
Former ID
DIB000502
Drug Name
AMT-060
Synonyms
AAV gene therapy (hemophilia B), Amsterdam Molecular Therapeutics/St Jude
Indication Factor IX deficiency [ICD10:D67] Phase 1/2 [548603]
Company
Amsterdam Molecular Therapeutics BV
Target and Pathway
Target(s) Coagulation factor IX Target Info Modulator [550344]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
PathWhiz Pathway Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 548603Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026919)
Ref 550344Phase I/II clinical trial of AMT-060 for treating hemophilia B. uniQure N.V.

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