Drug Information

Drug General Information
Drug ID
D0A6CQ
Former ID
DAP001396
Drug Name
Levobetaxolol
Synonyms
Levobetaxolol [INN]; Betaxon (TN); (-)-Betaxolol; (2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol; (2S)-1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol; (2s)-1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(isopropylamino)propan-2-ol; (S)-(-)-Betaxolol; (S)-1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol; (S)-Betaxolol
Drug Type
Small molecular drug
Indication Chronic open-angle glaucoma; Ocular hypertension [ICD10:H40] Approved [551871]
Therapeutic Class
Cardiotonic Agents
Company
Alcon Pharmaceuticals Ltd
Formula
C18H29NO3
InChI
InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m0/s1
InChIKey
NWIUTZDMDHAVTP-KRWDZBQOSA-N
CAS Number
CAS 116209-55-3
PubChem Compound ID
60657
PubChem Substance ID
8186984, 14752035, 14898713, 43118020, 50065394, 50655309, 56413040, 57314053, 92741948, 94569129, 104321311, 117556010, 117880015, 131271782, 131850800, 134338604, 134487783, 135107063, 135928399, 137249363, 138985391, 162179211, 175269493, 179151450, 198967634, 226412211, 249565715
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [535957]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535957Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors. J Ocul Pharmacol Ther. 2004 Apr;20(2):93-9.

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