Drug Information

Drug General Information
Drug ID
D0A4MM
Former ID
DNC008432
Drug Name
NE-10575
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540163]
Formula
C8H14NO7P2+
InChI
InChI=1S/C8H13NO7P2/c1-9-4-2-3-7(6-9)5-8(10,17(11,12)13)18(14,15)16/h2-4,6,10H,5H2,1H3,(H3-,11,12,13,14,15,16)/p+1
InChIKey
BBNRLGQPSIXFHZ-UHFFFAOYSA-O
PubChem Compound ID
9847474
PubChem Substance ID
44945541, 56239903, 78794345, 103314244, 123054258, 123055261, 127491705, 134345637, 135650696, 137744578, 160852200, 233902940
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [529362]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 540163(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3184).
Ref 529362J Med Chem. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

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