Drug Information

Drug General Information
Drug ID
D0A0SI
Former ID
DNCL003393
Drug Name
BAY 85-8501
Indication Bronchiectasis [ICD9: 494, 748.61; ICD10:J47, Q33.4] Phase 2 [549458]
Company
Bayer HealthCare Pharmaceuticals
Target and Pathway
Target(s) Leukocyte elastase Target Info Modulator [533269]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 549458Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037600)
Ref 533269Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY??5-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.

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