Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09YHQ
|
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| Former ID |
DNC008056
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| Drug Name |
9-chlorobenzo[h]isoquinolin-1(2H)-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [529069] | ||
| Formula |
C13H8ClNO
|
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| Canonical SMILES |
C1=CC2=C(C3=C1C=CC(=C3)Cl)C(=O)NC=C2
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| InChI |
1S/C13H8ClNO/c14-10-4-3-8-1-2-9-5-6-15-13(16)12(9)11(8)7-10/h1-7H,(H,15,16)
|
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| InChIKey |
XSQDWQSZUGGKPF-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [529069] | |
| Pathway Interaction Database | Fanconi anemia pathway | ||||
| p73 transcription factor network | |||||
| ATR signaling pathway | |||||
| Circadian rhythm pathway | |||||
| p53 pathway | |||||
| Reactome | Activation of ATR in response to replication stress | ||||
| Processing of DNA double-strand break ends | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| G2/M DNA damage checkpoint | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
| References | |||||
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