Drug Information

Drug General Information
Drug ID
D09UVB
Former ID
DIB020017
Drug Name
HTMT
Synonyms
histamine-trifluoromethyl-toluidine; histamine-trifluoromethyltoluide; HTFMT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538787]
Formula
C19H25F3N4O
InChI
InChI=1S/C19H25F3N4O/c1-14(24-11-10-17-12-23-13-25-17)4-2-3-5-18(27)26-16-8-6-15(7-9-16)19(20,21)22/h6-9,12-14,24H,2-5,10-11H2,1H3,(H,23,25)(H,26,27)
InChIKey
PMKJGGBYYNEYPA-UHFFFAOYSA-N
PubChem Compound ID
124846
PubChem Substance ID
4345729, 14804711, 15004238, 26751819, 29304795, 53439012, 53911441, 57309642, 57341085, 85230024, 85788608, 103259856, 104421786, 126435538, 128937063, 135081308, 135650354, 137128387, 139426851, 162222024, 179447910
Target and Pathway
Target(s) Histamine H4 receptor Target Info Agonist [525965]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538787(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1273).
Ref 525965Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol. 2001 Mar;59(3):434-41.

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