Drug Information

Drug General Information
Drug ID
D09PTA
Former ID
DIB002342
Drug Name
HP-290
Synonyms
NXX-066
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Discontinued in Phase 2 [546136]
Company
Astra AB; Hoechst AG
Formula
C23H27N3O2
Canonical SMILES
[C@]12([C@@H](N(c3c1cc(OC(=O)N1Cc4c(CC1)cccc4)cc3)C)N(C<br />C2)C)C
CAS Number
CAS 139314-01-5
PubChem Compound ID
132228
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [525471]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 546136Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006532)
Ref 525471NXX-066 in patients with Alzheimer's disease: a bridging study. Life Sci. 1999;64(14):1215-21.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.