Drug Information

Drug General Information
Drug ID
D09PJK
Former ID
DIB000396
Drug Name
ACK-1 inhibitors
Synonyms
ACK-1 inhibitors (cancer); ACK-1 inhibitors (cancer), Amgen; Activated Cdc42Hs-associated tyrosine kinase-1 inhibitors (cancer), Amgen
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [552118]
Company
Amgen Inc
Canonical SMILES
C1CCCN1CCOc1c(cc(cc1)Nc1ncc2c(n1)n(nc2Nc1c(cccc1C)C)CCC<br />(C)(C)OC)F
Target and Pathway
Target(s) Activated CDC42 kinase 1 Target Info Inhibitor [543581]
NetPath Pathway TSH Signaling Pathway
Pathway Interaction Database CDC42 signaling events
WikiPathways G13 Signaling Pathway
EGF/EGFR Signaling Pathway
Focal Adhesion
References
Ref 552118Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6212-7
Ref 543581(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2246).

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