Drug Information

Drug General Information
Drug ID
D09OWK
Former ID
DIB002896
Drug Name
AGN-2979
Synonyms
BTG-1501; SC-48274; AGN-2979 (free base); 3-[3-(Dimethylamino)propyl]-3-(3-methoxyphenyl)-4,4-dimethylpiperidine-2,6-dione; 3-[3-(Dimethylamino)propyl]-3-(3-methoxyphenyl)-4,4-dimethylpiperidine-2,6-dione monohydrochloride
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Phase 2 [526166]
Formula
C19H28N2O3
Canonical SMILES
CC1(CC(=O)NC(=O)C1(CCCN(C)C)C2=CC(=CC=C2)OC)C
InChI
1S/C19H28N2O3/c1-18(2)13-16(22)20-17(23)19(18,10-7-11-21(3)4)14-8-6-9-15(12-14)24-5/h6,8-9,12H,7,10-11,13H2,1-5H3,(H,20,22,23)
InChIKey
UJFNSGBGJMRZKS-UHFFFAOYSA-N
PubChem Compound ID
40914
PubChem Substance ID
14875310, 34706626, 50016197, 76548776, 104335629, 126416026, 129376236, 135003158, 135126311, 137006078, 139570179, 144239786, 162220004, 162549563, 223913010, 229811559
Target and Pathway
Target(s) Tryptophan 5-hydroxylase-1 Target Info Modulator [526166]
BioCyc Pathway Superpathway of tryptophan utilization
Serotonin and melatonin biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
Serotonergic synapse
PANTHER Pathway 5-Hydroxytryptamine biosynthesis
PathWhiz Pathway Tryptophan Metabolism
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 526166Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
Ref 526166Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.

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