Drug Information

Drug General Information
Drug ID
D09KQM
Former ID
DIB009597
Drug Name
PYK2 inhibitors
Synonyms
PYK2 inhibitors (osteoporosis); FAK 2 inhibitors (osteoporosis), Pfizer; Focal adhesion kinase 2 inhibitors (osteoporosis), Pfizer; PYK2 inhibitors (osteoporosis), Pfizer; Proline-rich tyrosine kinase 2 inhibitors (osteoporosis), Pfizer
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Investigative [552045]
Company
Pfizer Inc
Canonical SMILES
N(=[S@@](=O)(c1ccc(Nc2ncc(C(F)(F)F)c(n2)N[C@H]2[C@H](N(<br />C)C)CCC2)cc1)C)C
Target and Pathway
Target(s) Focal adhesion kinase-2 Target Info Inhibitor [543570]
KEGG Pathway Calcium signaling pathway
Chemokine signaling pathway
Natural killer cell mediated cytotoxicity
Leukocyte transendothelial migration
GnRH signaling pathway
Hepatitis B
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Integrin signalling pathway
CCKR signaling map ST
Pathway Interaction Database Endothelins
LPA receptor mediated events
Coregulation of Androgen receptor activity
Osteopontin-mediated events
IL2-mediated signaling events
CXCR4-mediated signaling events
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Alpha-synuclein signaling
FGF signaling pathway
Alpha4 beta1 integrin signaling events
Reactome Signal regulatory protein (SIRP) family interactions
VEGFA-VEGFR2 Pathway
Interleukin-2 signaling
WikiPathways TCR Signaling Pathway
IL-2 Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Apoptosis-related network due to altered Notch3 in ovarian cancer
Interleukin-2 signaling
Nifedipine Activity
BDNF signaling pathway
Oncostatin M Signaling Pathway
Prostate Cancer
IL-7 Signaling Pathway
Signal regulatory protein (SIRP) family interactions
References
Ref 552045Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J Biol Chem. 2009 May 8;284(19):13193-201
Ref 543570(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2181).

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