Drug Information

Drug General Information
Drug ID
D09HTB
Former ID
DCL000635
Drug Name
SAR153191
Indication Ankylosing spondylitis [ICD9: 720; ICD10:M08.1, M45] Phase 3 [542912], [548704]
Company
Sanofi-Aventis
Target and Pathway
Target(s) Interleukin-6 receptor Target Info Antagonist [549823]
KEGG Pathway Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Non-alcoholic fatty liver disease (NAFLD)
Reactome MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
WikiPathways SIDS Susceptibility Pathways
Senescence and Autophagy in Cancer
IL-6 signaling pathway
Differentiation Pathway
Interleukin-6 signaling
References
Ref 542912(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7999).
Ref 548704Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027858)
Ref 549823Pharma & Vaccines. Product Development Pipeline. April 29 2009.

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