Drug Information

Drug General Information
Drug ID
D09EXD
Former ID
DAP000382
Drug Name
Rituximab
Synonyms
MAbThera (TN); Rituxan (TN)
Drug Type
Antibody
Indication Non-hodgkin's lymphoma [ICD10:C85] Approved [536940], [541860]
Hematologic malignancies [ICD9: 200-209; ICD10:C81-C86] Phase 1 [536940], [541860]
Therapeutic Class
Anticancer Agents
Company
Roche
Formula
C6416H9874N1688O1987S44
CAS Number
CAS 174722-31-7
PubChem Substance ID
17397150
SuperDrug ATC ID
L01XC02
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) B-lymphocyte antigen CD20 Target Info [535660], [536968]
KEGG Pathway Hematopoietic cell lineage
References
Ref 536940Disease-modifying agents for multiple sclerosis: recent advances and future prospects. Drugs. 2008;68(17):2445-68. doi: 10.2165/0003495-200868170-00004.
Ref 541860(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6780).
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 536968Contribution of radioimmunotherapy to the treatment of lymphoma. Ann Pharm Fr. 2008 Nov-Dec;66(5-6):300-8. Epub 2008 Nov 8.

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