Drug Information

Drug General Information
Drug ID
D08XYR
Former ID
DNC013658
Drug Name
DOM
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539013]
Formula
C12H19NO2
InChI
InChI=1S/C12H19NO2/c1-8-5-12(15-4)10(6-9(2)13)7-11(8)14-3/h5,7,9H,6,13H2,1-4H3
InChIKey
NTJQREUGJKIARY-UHFFFAOYSA-N
PubChem Compound ID
85875
PubChem Substance ID
7978580, 10221560, 10509196, 10516046, 15414462, 44417299, 46504804, 50004289, 57334104, 78158477, 85209384, 103111247, 103166957, 103918774, 104389663, 117533951, 124954066, 125705031, 128751983, 134350863, 134993569, 135650205, 137005387, 141288061, 160964775, 162821618, 179293624, 216396421, 226726881, 249527451, 249912022
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [529336]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539013(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 164).
Ref 529336Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. Epub 2008 Feb 14.The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.

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