Drug Information

Drug General Information
Drug ID
D08XNH
Former ID
DCL000373
Drug Name
GSK221149
Drug Type
Small molecular drug
Indication Threatened pre-term labour [ICD10:O60.1, P07.3] Phase 3 [548262]
Company
GSK
Formula
C11H13NO8
Canonical SMILES
C1=CC(=CC=C1[N+](=O)[O-])OC2C(C(C(C(O2)O)O)O)O
InChI
1S/C11H13NO8/c13-7-8(14)10(16)20-11(9(7)15)19-6-3-1-5(2-4-6)12(17)18/h1-4,7-11,13-16H/t7-,8-,9+,10-,11-/m0/s1
InChIKey
VZBHOPHDDNTGCY-HHKYUTTNSA-N
PubChem Compound ID
56603697
PubChem Substance ID
134339022
Target and Pathway
Target(s) Oxytocin receptor Target Info Antagonist [550963]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 548262Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023904)
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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