Drug Information

Drug General Information
Drug ID
D08VCI
Former ID
DNC000779
Drug Name
Ifenprodil
Drug Type
Small molecular drug
Indication Cancer pain [ICD9: 140-229, 338,780; ICD10:R52, G89] Withdrawn from market [533448], [540873]
Therapeutic Class
Analgesics
Formula
C21H27NO2
InChI
InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3
InChIKey
UYNVMODNBIQBMV-UHFFFAOYSA-N
PubChem Compound ID
3689
PubChem Substance ID
4725773, 8152332, 14752941, 24262973, 26751765, 29215029, 29222812, 47811044, 47960032, 49698431, 50016323, 50104451, 50104452, 53788156, 57321942, 77542351, 81041086, 85213187, 85787500, 90341159, 92308801, 96024756, 103856535, 103983044, 104304238, 118313765, 123121346, 124749897, 124886924, 124960908, 125345551, 126645206, 129438974, 134339686, 134339687, 135048478, 135697523, 137004977, 142433824, 144204466, 152034593, 162174615, 162222110, 163414206, 164786771, 170465791, 170485605, 172913925, 178102121, 179150197
SuperDrug ATC ID
C04AX28
SuperDrug CAS ID
cas=023210562
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 2 Target Info Antagonist [537247]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosus
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database ErbB4 signaling events
Reelin signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
BDNF signaling pathway
References
Ref 533448Effects of the novel 5-hydroxytryptamine reuptake inhibitor indalpine and ethanol on psychomotor performance. Arzneimittelforschung. 1988 Jan;38(1):98-102.
Ref 540873(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5472).
Ref 537247NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum. PLoS One. 2009;4(4):e5250. Epub 2009 Apr 21.

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