TTD | Drug: D08MDL

Drug General Information
Drug ID	D08MDL
Former ID	DIB020063
Drug Name	INS49266
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539118]
Formula	C25H25N5O11P2
InChI	InChI=1S/C25H25N5O11P2/c31-24(16-9-5-2-6-10-16)29-22-19-23(27-13-26-22)30(14-28-19)25-21-20(39-18(40-21)11-15-7-3-1-4-8-15)17(38-25)12-37-43(35,36)41-42(32,33)34/h1-10,13-14,17-18,20-21,25H,11-12H2,(H,35,36)(H2,32,33,34)(H,26,27,29,31)/t17-,18-,20-,21-,25-/m1/s1
InChIKey	VXEHVAOFCPIBTQ-XXXKQHFZSA-N
PubChem Compound ID	91827342
Target and Pathway
Target(s)	P2Y purinoceptor 12	Target Info	Antagonist	[529277]
KEGG Pathway	Platelet activation
Reactome	P2Y receptors
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539118	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1769).
Ref 529277	J Med Chem. 2008 Feb 28;51(4):1007-25. Epub 2008 Jan 31.Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor.

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Drug Information