Drug Information

Drug General Information
Drug ID
D08KIB
Former ID
DIB012830
Drug Name
SAR-114137
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 1 [532135]
Company
Sanofi
Target and Pathway
Target(s) Cathepsin S Target Info Inhibitor [532135]
Cathepsin K Target Info Inhibitor [532135]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Tuberculosishsa04142:Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway Leptin Signaling Pathway
IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
Activation of Matrix Metalloproteinases
MHC class II antigen presentation
WikiPathways Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLRWP2018:RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 532135From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
Ref 532135From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.

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