Drug Information

Drug General Information
Drug ID
D08HPZ
Former ID
DAP001448
Drug Name
Tocilizumab
Synonyms
Actemra; Actemra (TN); Tocilizumab (genetical recombination); Tocilizumab (USAN/INN); Tocilizumab (genetical recombination) (JAN)
Drug Type
Monoclonal antibody
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Approved [536711], [541938]
Juvenile idiopathic arthritis [ICD9: 714.3; ICD10:M08.0] Phase 3 [536711], [541938]
Company
Roche; Genentech
CAS Number
CAS 375823-41-9
PubChem Substance ID
17396767
SuperDrug ATC ID
L04AC07
Target and Pathway
Target(s) Interleukin-6 receptor Target Info Modulator [531351]
KEGG Pathway Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Non-alcoholic fatty liver disease (NAFLD)
Reactome MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
WikiPathways SIDS Susceptibility Pathways
Senescence and Autophagy in Cancer
IL-6 signaling pathway
Differentiation Pathway
Interleukin-6 signaling
References
Ref 536711Molecular targets of rheumatoid arthritis. Inflamm Allergy Drug Targets. 2008 Mar;7(1):53-66.
Ref 541938(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6881).
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.

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