Drug Information

Drug General Information
Drug ID
D08GJS
Former ID
DNC005861
Drug Name
3-(2-Dimethylamino-propyl)-1H-indol-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527668]
Formula
C13H18N2O
Canonical SMILES
CC(CC1=CNC2=C1C(=CC=C2)O)N(C)C
InChI
1S/C13H18N2O/c1-9(15(2)3)7-10-8-14-11-5-4-6-12(16)13(10)11/h4-6,8-9,14,16H,7H2,1-3H3
InChIKey
GRWDWEFPYLWISL-UHFFFAOYSA-N
PubChem Compound ID
44404906
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Inhibitor [527668]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [527668]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [527668]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 527668Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Ref 527668Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.

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