Drug Information

Drug General Information
Drug ID
D08GBT
Former ID
DIB010549
Drug Name
SAR-131675
Synonyms
VEGFR3 tyrosine kinase inhibitor (cancer), sanofi-aventis
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543500]
Company
Sanofi
Formula
C18H22N4O4
Canonical SMILES
CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#CC(C)(COC)O)C(=O)NC)N
InChI
1S/C18H22N4O4/c1-5-22-15(19)13(17(24)20-3)14(23)12-7-6-11(21-16(12)22)8-9-18(2,25)10-26-4/h6-7,25H,5,10,19H2,1-4H3,(H,20,24)/t18-/m1/s1
InChIKey
PFMPOBVAYMTUOX-GOSISDBHSA-N
PubChem Compound ID
71295845
PubChem Substance ID
162009749, 163438861, 163620895, 163686216, 185975114, 226087971, 240603174, 252216253, 252451249, 252473331, 252543436
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 3 Target Info Inhibitor [543500]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesion
NetPath Pathway TNFalpha Signaling Pathway
Pathway Interaction Database VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endothelium
Reactome VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Signaling by VEGF
References
Ref 543500(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1814).
Ref 543500(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1814).

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