Drug Information

Drug General Information
Drug ID
D08FWK
Former ID
DIB005900
Drug Name
Oxypurinol
Synonyms
Oxypurinol (intravenous)
Drug Type
Small molecular drug
Indication Heart failure [ICD9: 428; ICD10:I50] Phase 2/3 [521563]
Company
Johns Hopkins University
Formula
C5H4N4O2
Canonical SMILES
O=C1NC(=O)c2c[nH]nc2N1
InChI
1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
InChIKey
HXNFUBHNUDHIGC-UHFFFAOYSA-N
PubChem Compound ID
4644
Target and Pathway
Target(s) Xanthine dehydrogenase/oxidase Target Info Inhibitor [533356]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides degradation
Adenosine nucleotides degradation
Retinoate biosynthesis II
KEGG Pathway Purine metabolism
Caffeine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Peroxisome
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Purine metabolism
PathWhiz Pathway Caffeine Metabolism
Purine Metabolism
Reactome Purine catabolism
WikiPathways Oxidative Stress
Effects of Nitric Oxide
Metabolism of nucleotides
Selenium Micronutrient Network
References
Ref 521563ClinicalTrials.gov (NCT00063687) Oxypurinol Compared With Placebo for Class III-IV NYHA Congestive Heart Failure. U.S. National Institutes of Health.
Ref 533356Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical. Biochem Pharmacol. 1988 Jan 15;37(2):349-52.

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