Drug Information

Drug General Information
Drug ID
D08ATZ
Former ID
DIB020783
Drug Name
QO-58
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542647]
Formula
C18H8Cl2F4N4O
InChI
InChI=1S/C18H8Cl2F4N4O/c19-15-9(6-10(21)16(20)26-15)11-7-12(29)28-17(25-11)13(8-4-2-1-3-5-8)14(27-28)18(22,23)24/h1-7,25H
InChIKey
JEXACLGXUUYXDX-UHFFFAOYSA-N
PubChem Compound ID
51351551
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 2 Target Info Activator [532057]
KEGG Pathway Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Voltage gated Potassium channels
Interaction between L1 and Ankyrins
WikiPathways Potassium Channels
L1CAM interactions
References
Ref 542647(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7669).
Ref 532057Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol. 2013 Feb;168(4):1030-42.

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