Drug Information

Drug General Information
Drug ID
D08AGH
Former ID
DIB018188
Drug Name
[18F]altanserin
Synonyms
[18F]altanserin (PET ligand)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540215]
Formula
C22H22FN3O2S
InChI
InChI=1S/C22H22FN3O2S/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)/i23-1
InChIKey
SMYALUSCZJXWHG-VNRZBHCFSA-N
PubChem Compound ID
5312287
PubChem Substance ID
108, 1615, 7982030, 11057002, 16779951, 39341900, 50849699, 114158381, 135651121, 140411885, 237676275, 246848659
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [534323]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540215(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3242).
Ref 534323Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging. Psychiatry Res. 1996 Nov 25;68(1):11-22.

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