Drug Information

Drug General Information
Drug ID
D07YMX
Former ID
DIB012062
Drug Name
RPC-1063
Synonyms
S1P1 agonists (multiple sclerosis/autoimmune diseases), Receptos; Sphingosine-1-phosphate type 1 receptoragonists (multiple sclerosis/autoimmune diseases), Receptos
Indication Advanced non-small cell lung cancer [ICD9: 162; ICD10:C33-C34] Phase 3 [525004]
Company
Receptos
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [532456]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 525004ClinicalTrials.gov (NCT02294058) Phase 3 Study of RPC1063 in Relapsing MS. U.S. National Institutes of Health.
Ref 532456Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.

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