TTD | Drug: D07XLJ

Drug General Information
Drug ID	D07XLJ
Former ID	DNC004818
Drug Name	N6-Benzyl-quinazoline-2,4,6-triamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527455]
Formula	C15H15N5
Canonical SMILES	C1=CC=C(C=C1)CNC2=CC3=C(C=C2)N=C(N=C3N)N
InChI	1S/C15H15N5/c16-14-12-8-11(6-7-13(12)19-15(17)20-14)18-9-10-4-2-1-3-5-10/h1-8,18H,9H2,(H4,16,17,19,20)
InChIKey	PTWJNRZKGULCMJ-UHFFFAOYSA-N
PubChem Compound ID	462120
Target and Pathway
Target(s)	Dihydrofolate reductase	Target Info	Inhibitor	[527455]
PathWhiz Pathway	Folate Metabolism
PathWhiz Pathway	Pterine Biosynthesis
Reactome	E2F mediated regulation of DNA replication
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Metabolism of folate and pterines
	G1/S-Specific Transcription
References
Ref 527455	J Med Chem. 2005 Mar 10;48(5):1448-69.CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase.
Ref 527455	J Med Chem. 2005 Mar 10;48(5):1448-69.CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase.

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Drug Information