Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07UPJ
|
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| Former ID |
DIB014003
|
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| Drug Name |
NMDA NR2B antagonists
|
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| Synonyms |
NMDA NR2B antagonists (depression); NMDA NR2B antagonists (depression), AstraZeneca
|
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| Indication | Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] | Investigative | [552160] | ||
| Company |
AstraZeneca plc
|
||||
| Canonical SMILES |
c1c(ccc(c1OC)c1cc(cnc1)CNC1CCCC1)F
|
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| Target and Pathway | |||||
| Target(s) | Glutamate [NMDA] receptor subunit epsilon 2 | Target Info | Antagonist | [543838] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Long-term potentiation | |||||
| Glutamatergic synapse | |||||
| Dopaminergic synapse | |||||
| Alzheimer's disease | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Huntington's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Nicotine addiction | |||||
| Alcoholism | |||||
| Systemic lupus erythematosus | |||||
| Pathway Interaction Database | ErbB4 signaling events | ||||
| Reelin signaling pathway | |||||
| References | |||||
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