Drug Information

Drug General Information
Drug ID
D07TSW
Former ID
DNC011282
Drug Name
SALACINOL
Drug Type
Small molecular drug
Indication Discovery agent Phase 1/2 [521814]
Formula
C9H18O9S2
Canonical SMILES
C1C(C(C([S+]1CC(C(CO)OS(=O)(=O)[O-])O)CO)O)O
InChI
1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6-,7+,8-,9+,19?/m1/s1
InChIKey
SOWRVDSZMRPKRG-XESHOGEWSA-N
PubChem Compound ID
6451151
Target and Pathway
Target(s) Maltase-glucoamylase, intestinal Target Info Inhibitor [531230]
Lysosomal alpha-glucosidase Target Info Inhibitor [529528]
KEGG Pathway Galactose metabolism
Starch and sucrose metabolism
Metabolic pathways
Carbohydrate digestion and absorptionhsa00052:Galactose metabolism
Lysosome
Pathway Interaction Database Notch-mediated HES/HEY network
PathWhiz Pathway Starch and Sucrose MetabolismPW000159:Galactose Metabolism
WikiPathways Metabolism of carbohydrates
References
Ref 521814ClinicalTrials.gov (NCT00306072) Effect of Different Doses of Salacinol Extract on Glycemic and Insulinemic Response in Patients With Type 2 Diabetes. U.S. National Institutes of Health.
Ref 529528J Nat Prod. 2008 Jun;71(6):981-4. Epub 2008 Jun 12.Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).
Ref 531230Bioorg Med Chem. 2010 Nov 15;18(22):7794-8. Epub 2010 Sep 29.Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of asix-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.

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