Drug Information

Drug General Information
Drug ID
D07RTQ
Former ID
DIB020478
Drug Name
NAADP
Synonyms
nicotinic acid adenine dinucleotide phosphate; NAADP+
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539579]
Formula
C21H28N6O18P3+
InChI
InChI=1S/C21H27N6O18P3/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(44-46(33,34)35)14(29)11(43-20)6-41-48(38,39)45-47(36,37)40-5-10-13(28)15(30)19(42-10)26-3-1-2-9(4-26)21(31)32/h1-4,7-8,10-11,13-16,19-20,28-30H,5-6H2,(H6-,22,23,24,31,32,33,34,35,36,37,38,39)/p+1/t10-,11-,13-,14-,15-,16-,19-,20-/m1/s1
InChIKey
QOTXBMGJKFVZRD-HISDBWNOSA-O
PubChem Compound ID
123953
PubChem Substance ID
583440, 29304117, 53801022, 57282638, 57340674, 75206894, 104419731, 162023753, 164347278, 177011836
Target and Pathway
Target(s) Long transient receptor potential channel 2 Target Info Activator [528116]
P2Y11 receptor Target Info Agonist [528990]
Reactome TRP channels
References
Ref 539579(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2450).
Ref 528116Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J. 2006 May;20(7):962-4. Epub 2006 Apr 3.
Ref 528990NAADP+ is an agonist of the human P2Y11 purinergic receptor. Cell Calcium. 2008 Apr;43(4):344-55. Epub 2007 Aug 17.

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