Drug Information

Drug General Information
Drug ID
D07PSL
Former ID
DIB013734
Drug Name
PLX7486
Indication Pancreatic cancer [ICD9: 140-199, 140-229, 157, 210-229; ICD10:C25] Phase 1 [549504]
Company
Daiichi sankyo
Target and Pathway
Target(s) Neurotrophic tyrosine kinase receptor 1 Target Info Inhibitor [550497]
Macrophage colony-stimulating factor receptor Target Info Inhibitor [550497]
KEGG Pathway MAPK signaling pathway
Endocytosis
Apoptosis
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Central carbon metabolism in cancerhsa04060:Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
NetPath Pathway IL2 Signaling PathwayNetPath_22:Leptin Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Neurotrophic factor-mediated Trk receptor signaling
Reactome Frs2-mediated activation
ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activation
WikiPathways MAPK Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membrane
References
Ref 549504Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038879)
Ref 550497National Cancer Institute Drug Dictionary (drug id 747694).

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