Drug Information

Drug General Information
Drug ID
D07OQZ
Former ID
DIB003539
Drug Name
Adenosine A2b antagonists
Synonyms
Adenosine A2b antagonists, Hoffman-La Roche
Indication Asthma [ICD10:J45] Investigative [552096]
Company
Roche Holding AG
Canonical SMILES
O=S(=O)(c1cc(C(F)(F)F)ccc1)C1CCN(C(=O)Nc2nc3c(ccc(c3s2)<br />N(CC)C(=O)C)OC)CC1
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [543534]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 552096Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1933-6
Ref 543534(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20).

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