Drug Information

Drug General Information
Drug ID
D07NOI
Former ID
DCL000356
Drug Name
BAY-57-9352
Synonyms
Telatinib; Bay 57-9352
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [548058]
Therapeutic Class
Anticancer Agents
Company
Bayer AG
Formula
C20H16ClN5O3
Canonical SMILES
CNC(=O)C1=NC=CC(=C1)COC2=NN=C(C3=C2OC=C3)NC4=CC=C(C=C4)<br />Cl
InChI
1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)
InChIKey
QFCXANHHBCGMAS-UHFFFAOYSA-N
CAS Number
CAS 332012-40-5
PubChem Compound ID
9808844
PubChem Substance ID
14831018, 24115824, 44844835, 75059184, 123051133, 124360774, 124757885, 124955475, 125164687, 126661316, 126731532, 131477698, 135260928, 135367560, 136348776, 136349488, 136367619, 136367765, 137156647, 143010267, 152048944, 160680893, 162011760, 162038009, 162202687, 163348562, 163908069, 164042063, 164765235, 170502613, 172919643, 174528808, 198939231, 223396209, 223705027, 227479450, 242060040, 245318899, 251971207, 252110147, 252216386
Target and Pathway
Target(s) Platelet-derived growth factor receptor Target Info Inhibitor [536474]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [536474]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancer
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY network
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WikiPathways Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
Angiogenesis
References
Ref 548058Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021605)
Ref 536474A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.

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