Drug Information

Drug General Information
Drug ID
D07LRT
Former ID
DCL000025
Drug Name
A-425619
Synonyms
AC1OYT5J; T5512318; LS-192912; 1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea; 1-isoquinolin-5-yl-3-[[4-(trifluoromethyl)phenyl]methyl]urea
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Preclinical [467460], [548222]
Therapeutic Class
Analgesics
Company
Abbott
Formula
C18H14F3N3O
InChI
InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)
InChIKey
SJGVXVZUSQLLJB-UHFFFAOYSA-N
PubChem Compound ID
8068410
PubChem Substance ID
14952509, 17330319, 39642896, 49688408, 50076144, 52397350, 85177293, 91986601, 103321580, 115791867, 118873568, 125644896, 126922872, 131319701, 134338737, 135283965, 135693599, 137215455, 139541467, 163284467, 163642463, 169401759, 178100939, 198962273, 223942932, 228815712, 248662546
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker [537396]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 467460(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4117).
Ref 548222Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023258)
Ref 537396Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. Epub 2009 Mar 5.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.