Drug Information

Drug General Information
Drug ID
D07JSK
Former ID
DIB004697
Drug Name
Sulotroban
Synonyms
BM-13177; SKF-95587
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [544519]
Company
Boehringer Mannheim GmbH
Formula
C16H17NO5S
Canonical SMILES
S(=O)(=O)(c1ccccc1)NCCc1ccc(OCC(=O)O)cc1
CAS Number
CAS 72131-33-0
PubChem Compound ID
51550
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Modulator [532727]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 544519Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000039)
Ref 532727The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation. Prostaglandins. 1988 Dec;36(6):751-60.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.