Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07JOZ
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| Former ID |
DNC009341
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| Drug Name |
1,1':4',1''-terphenyl-3,3''-diol
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| Synonyms |
[1,1':4',1'']Terphenyl-3,3''-diol
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [530450] | ||
| Formula |
C18H13FO2
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| Canonical SMILES |
C1=CC(=CC(=C1)O)C2=CC=C(C=C2)C3=CC(=C(C=C3)O)F
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| InChI |
1S/C18H13FO2/c19-17-11-15(8-9-18(17)21)13-6-4-12(5-7-13)14-2-1-3-16(20)10-14/h1-11,20-21H
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| InChIKey |
JNOWDEFWQPRYLB-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Cytochrome P450 3A4 | Target Info | Inhibitor | [529748] | |
| Estradiol 17 beta-dehydrogenase 1 | Target Info | Inhibitor | [530450] | ||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Linoleic acid metabolism | |||||
| Retinol metabolism | |||||
| Metabolism of xenobiotics by cytochrome P450 | |||||
| Drug metabolism - cytochrome P450 | |||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathways | |||||
| Bile secretion | |||||
| Chemical carcinogenesishsa00140:Steroid hormone biosynthesis | |||||
| Ovarian steroidogenesis | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
| WikiPathways | Metapathway biotransformation | ||||
| Aflatoxin B1 metabolism | |||||
| Estrogen metabolism | |||||
| Benzo(a)pyrene metabolism | |||||
| Tamoxifen metabolism | |||||
| Tryptophan metabolism | |||||
| Oxidation by Cytochrome P450 | |||||
| Nuclear Receptors in Lipid Metabolism and Toxicity | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Farnesoid X Receptor Pathway | |||||
| Vitamin D Receptor Pathway | |||||
| Felbamate Metabolism | |||||
| Lidocaine metabolism | |||||
| Nifedipine Activity | |||||
| Colchicine Metabolic Pathway | |||||
| Irinotecan Pathway | |||||
| Drug Induction of Bile Acid Pathway | |||||
| Fatty Acid Omega Oxidation | |||||
| Codeine and Morphine MetabolismWP496:Steroid Biosynthesis | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| Prostate Cancer | |||||
| References | |||||
| Ref 529748 | J Med Chem. 2008 Nov 13;51(21):6725-39. Epub 2008 Oct 15.Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). | ||||
| Ref 530450 | J Med Chem. 2009 Nov 12;52(21):6724-43.New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity. | ||||
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