Drug Information

Drug General Information
Drug ID
D07GUB
Former ID
DIB019762
Drug Name
DL-TBOA
Synonyms
dl-threo-beta-benzyloxyaspartate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467871]
Formula
C11H13NO5
InChI
InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
InChIKey
BYOBCYXURWDEDS-IUCAKERBSA-N
PubChem Compound ID
5311218
PubChem Substance ID
7979716, 11113972, 14773995, 24277313, 39340926, 57359395, 74444196, 103281293, 103991661, 114155577, 127586563, 135698422, 137245175, 139767562, 162485052, 178101349, 232760229
Target and Pathway
Target(s) Excitatory amino acid transporter 1 Target Info Inhibitor [534556]
Excitatory amino acid transporter 3 Target Info Inhibitor [525905]
Excitatory amino acid transporter 5 Target Info Inhibitor [526179]
Excitatory amino acid transporter 2 Target Info Inhibitor [534556]
Excitatory amino acid transporter 4 Target Info Inhibitor [526179]
PANTHER Pathway Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
WikiPathways Amyotrophic lateral sclerosis (ALS)
References
Ref 467871(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4631).
Ref 525905Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2407-10.
Ref 526179Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J Neurochem. 2001 Oct;79(2):297-302.
Ref 534556DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol. 1998 Feb;53(2):195-201.

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