Drug Information

Drug General Information
Drug ID
D07GTX
Former ID
DNC012708
Drug Name
(8-Hydroxy-2-oxo-2H-quinolin-1-yl)-acetic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533420]
Formula
C11H9NO4
Canonical SMILES
C1=CC2=C(C(=C1)O)N(C(=O)C=C2)CC(=O)O
InChI
1S/C11H9NO4/c13-8-3-1-2-7-4-5-9(14)12(11(7)8)6-10(15)16/h1-5,13H,6H2,(H,15,16)
InChIKey
YRQSYBRKGTYSAL-UHFFFAOYSA-N
PubChem Compound ID
13683079
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [533420]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 533420J Med Chem. 1986 Oct;29(10):2024-8.Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives.
Ref 533420J Med Chem. 1986 Oct;29(10):2024-8.Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives.

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