Drug Information

Drug General Information
Drug ID
D07GTW
Former ID
DIB002811
Drug Name
Cyclic pyranopterin monophosphate
Synonyms
CPMP; CPMP (molybdenum cofactor deficiency), Alexion; CPMP (molybdenum cofactor deficiency), Orphatec
Drug Type
Small molecular drug
Indication Encephalopathy [ICD10:G93.4] Phase 2 [524617]
Company
Orphatec Pharmaceuticals GmbH
Formula
C10H14N5O8P
Canonical SMILES
OP1(=O)OCC2OC3Nc4nc([nH]c(=O)c4NC3C(O)(O)C2O1)N
PubChem Compound ID
25245619
Target and Pathway
Target(s) Xanthine dehydrogenase/oxidase Target Info Cofactor [530850]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides degradation
Adenosine nucleotides degradation
Retinoate biosynthesis II
KEGG Pathway Purine metabolism
Caffeine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Peroxisome
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Purine metabolism
PathWhiz Pathway Caffeine Metabolism
Purine Metabolism
Reactome Purine catabolism
WikiPathways Oxidative Stress
Effects of Nitric Oxide
Metabolism of nucleotides
Selenium Micronutrient Network
References
Ref 524617ClinicalTrials.gov (NCT02047461) Safety & Efficacy Study of ALXN1101 in Pediatric Patients With MoCD Type A Currently Treated With rcPMP. U.S. National Institutes of Health.
Ref 530850Successful treatment of molybdenum cofactor deficiency type A with cPMP. Pediatrics. 2010 May;125(5):e1249-54.

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