Drug Information

Drug General Information
Drug ID
D07DOW
Former ID
DNC007629
Drug Name
(1H-pyrazol-1-yl)(o-tolyl)methanone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529037]
Formula
C11H10N2O
Canonical SMILES
CC1=CC=CC=C1C(=O)N2C=CC=N2
InChI
1S/C11H10N2O/c1-9-5-2-3-6-10(9)11(14)13-8-4-7-12-13/h2-8H,1H3
InChIKey
RYSRFZOAAPABLM-UHFFFAOYSA-N
PubChem Compound ID
685230
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [529037]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 529037J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
Ref 529037J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.

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